Defiance, Missouri is an unincorporated community in Saint Charles County, Missouri. It was named in the late 1800s. Defiance is located approximately 40 miles west of St. Louis. Ivy has described it as a "cornfield-mosquito-ranch in the middle of nowhere".
In the comic
In "Defiance", Viktor tells Rocky that he can procure quality alcohol in Defiance. Rocky and Ivy journey to a farm located in Defiance in "Begorra", finding a spring house filled with bottles of liquor. There is a cemetary located near the farm, as shown in "Dead-run".
Rocky and Ivy are chased by a hearse before they can enter the spring house, and Rocky is injured and rendered unconscious during the pursuit. It is revealed that there were two men in the car; the passenger refers to the driver as an "ordained maniac" in "Haymaker".
In "Gravediggers", Bobby relates the story of his, Elsa's and Abelard's involvement with Lackadaisy - during the early days of Prohibition, when Atlas was still developing his empire, he arranged, possibly with Ruby's help, to have trains arriving in Defiance loaded with liquor. Bobby, Abelard and Elsa would store the liquor for Atlas. At some point, "cattle rustling, train robbing rabble" began to rob from them, going so far as to shoot their organ player. Atlas in turn brought Viktor and Mordecai to Defiance; upon catching one of the rabble, they began burying him alive until he provided them with further information - the liquor that the rabble was stealing was in turn being sold to "boys from the city", who were involved in a turf war with Marigold. At this point Bobby is cut off by Elsa, who asks him not to tell Ivy more "awful stories", though Ivy is eager to hear more.