Defiance, Missouri is an unincorporated community in Saint Charles County, Missouri. It was named in the late 1800s. Defiance is located approximately 40 miles west of St. Louis. Ivy has described it as a "cornfield-mosquito-ranch in the middle of nowhere".
In the comic
In "Defiance", Viktor tells Rocky that he can procure quality alcohol in Defiance. Rocky and Ivy journey to a farm located in Defiance in "Begorra", finding a spring house filled with bottles of liquor. There is a cemetary located near the farm, as shown in "Dead-run".
Rocky and Ivy are chased by a hearse before they can enter the spring house, and Rocky is injured and rendered unconscious during the pursuit. It is revealed that there were two men in the car; the passenger refers to the driver as an "ordained maniac" in "Haymaker".